In the two-group classification, AML samples are basically clustered together tightly no matter rows are scaled are not. The big overlap between also due to the difference between AML samples and ALL samples or at least a subset of ALL samples. As we observed from cola results, samples can also be separated into three groups where ALL samples are separated into two groups.

Consensus heatmaps three groups

In the three-group classification, when rows are scaled, only ATC:skmeans generates stable partition with 1-PAC score 0.96, while when rows are not scaled, none method generates stable partition.

Rows are scaled

Figure 8A. Consensus heatmaps with k = 3

Figure 8A. Consensus heatmaps with k = 3

Rows are unscaled

Figure 8B. Consensus heatmaps with k = 3

Figure 8B. Consensus heatmaps with k = 3

We pick the three-group classification from ATC:skmeans for the scaled case, and … On the other hand, the original Golub study classify ALL samples into B-cell and T-cell groups by SOM method. Note their method was applied on the whole expression matrix that are not scaled.

Figure 10.

Figure 10.

The two classifications are both separated…

Signature genes

ATC:skmeans, rows are scaled

Figure 11A

Figure 11A

SD:skmeans, row are unscaled

Figure 11B

Figure 11B

Only look at ALL samples

The overlap between the two sets of classification becomes large. We .. it due to the difference from AML group.

For the classification.. we removed the samples with label 1 in either classifications. ANd we applied t-test between group 2 and group 3 …

Figure 13.

Figure 13.

If look at the overlap between … the two sets are quite exclusive.

Figure 14

Figure 14

Since now the two sets of signatures are … we next check the biological functions that are enriched in the two sets of genes.

Gene ontology enrichment

C_{s,3}

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0009725 response to hormone 108/966 920/17913 0e+00 0.0000 108
GO:0010243 response to organonitrogen compound 107/966 932/17913 0e+00 0.0000 107
GO:1901699 cellular response to nitrogen compound 80/966 620/17913 0e+00 0.0000 80
GO:0071417 cellular response to organonitrogen compound 73/966 559/17913 0e+00 0.0000 73
GO:0044419 interspecies interaction between organisms 102/966 928/17913 0e+00 0.0000 102
GO:0016071 mRNA metabolic process 92/966 815/17913 0e+00 0.0000 92
GO:0007167 enzyme linked receptor protein signaling pathway 103/966 968/17913 0e+00 0.0000 103
GO:0014070 response to organic cyclic compound 96/966 879/17913 0e+00 0.0000 96
GO:0033993 response to lipid 96/966 884/17913 0e+00 0.0000 96
GO:0044403 symbiont process 96/966 884/17913 0e+00 0.0000 96
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 79/966 669/17913 0e+00 0.0000 79
GO:0051050 positive regulation of transport 100/966 942/17913 0e+00 0.0000 100
GO:0032870 cellular response to hormone stimulus 77/966 647/17913 0e+00 0.0000 77
GO:0042493 response to drug 101/966 958/17913 0e+00 0.0000 101
GO:0019725 cellular homeostasis 90/966 814/17913 0e+00 0.0000 90
GO:0016032 viral process 90/966 822/17913 0e+00 0.0000 90
GO:1901652 response to peptide 61/966 491/17913 0e+00 0.0000 61
GO:0009894 regulation of catabolic process 94/966 916/17913 0e+00 0.0000 94
GO:0036293 response to decreased oxygen levels 50/966 365/17913 0e+00 0.0000 50
GO:0001666 response to hypoxia 49/966 354/17913 0e+00 0.0000 49
GO:0070482 response to oxygen levels 52/966 389/17913 0e+00 0.0000 52
GO:0008380 RNA splicing 56/966 440/17913 0e+00 0.0000 56
GO:0031329 regulation of cellular catabolic process 85/966 814/17913 0e+00 0.0000 85
GO:1901653 cellular response to peptide 49/966 364/17913 0e+00 0.0000 49
GO:0019221 cytokine-mediated signaling pathway 81/966 764/17913 0e+00 0.0000 81
GO:0042327 positive regulation of phosphorylation 95/966 955/17913 0e+00 0.0000 95
GO:0048534 hematopoietic or lymphoid organ development 90/966 890/17913 0e+00 0.0000 90
GO:0009611 response to wounding 73/966 665/17913 0e+00 0.0000 73
GO:0000165 MAPK cascade 89/966 882/17913 0e+00 0.0000 89
GO:0051169 nuclear transport 43/966 305/17913 0e+00 0.0000 43
GO:0002520 immune system development 93/966 938/17913 0e+00 0.0000 93
GO:0023014 signal transduction by protein phosphorylation 89/966 886/17913 0e+00 0.0000 89
GO:0043620 regulation of DNA-templated transcription in response to stress 24/966 115/17913 0e+00 0.0000 24
GO:1903311 regulation of mRNA metabolic process 40/966 275/17913 0e+00 0.0000 40
GO:1903530 regulation of secretion by cell 75/966 703/17913 0e+00 0.0000 75
GO:0051046 regulation of secretion 79/966 757/17913 0e+00 0.0000 79
GO:0055082 cellular chemical homeostasis 72/966 666/17913 0e+00 0.0000 72
GO:0006913 nucleocytoplasmic transport 42/966 302/17913 0e+00 0.0000 42
GO:0000375 RNA splicing, via transesterification reactions 46/966 348/17913 0e+00 0.0000 46
GO:0006886 intracellular protein transport 84/966 833/17913 0e+00 0.0000 84
GO:0030097 hemopoiesis 85/966 847/17913 0e+00 0.0000 85
GO:0007417 central nervous system development 91/966 935/17913 0e+00 0.0000 91
GO:0006397 mRNA processing 58/966 499/17913 0e+00 0.0000 58
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 45/966 344/17913 0e+00 0.0000 45
GO:0000398 mRNA splicing, via spliceosome 45/966 344/17913 0e+00 0.0000 45
GO:0048511 rhythmic process 40/966 287/17913 0e+00 0.0000 40
GO:0033238 regulation of cellular amine metabolic process 19/966 80/17913 0e+00 0.0000 19
GO:0060341 regulation of cellular localization 85/966 863/17913 0e+00 0.0000 85
GO:0001934 positive regulation of protein phosphorylation 88/966 907/17913 0e+00 0.0000 88
GO:0048732 gland development 51/966 422/17913 0e+00 0.0000 51
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 22/966 109/17913 0e+00 0.0000 22
GO:0060322 head development 75/966 738/17913 0e+00 0.0000 75
GO:0033674 positive regulation of kinase activity 60/966 541/17913 0e+00 0.0000 60
GO:0006887 exocytosis 84/966 862/17913 0e+00 0.0000 84
GO:0046883 regulation of hormone secretion 36/966 254/17913 0e+00 0.0000 36
GO:0050852 T cell receptor signaling pathway 29/966 180/17913 0e+00 0.0000 29
GO:0023061 signal release 51/966 433/17913 0e+00 0.0000 51
GO:1905330 regulation of morphogenesis of an epithelium 29/966 181/17913 0e+00 0.0000 29
GO:0090087 regulation of peptide transport 72/966 706/17913 0e+00 0.0000 72
GO:0002444 myeloid leukocyte mediated immunity 60/966 549/17913 0e+00 0.0000 60
GO:0043069 negative regulation of programmed cell death 87/966 916/17913 0e+00 0.0000 87
GO:0048545 response to steroid hormone 46/966 375/17913 0e+00 0.0000 46
GO:0098657 import into cell 75/966 751/17913 0e+00 0.0000 75
GO:0002283 neutrophil activation involved in immune response 55/966 488/17913 0e+00 0.0000 55
GO:0050778 positive regulation of immune response 79/966 809/17913 0e+00 0.0000 79
GO:0043066 negative regulation of apoptotic process 85/966 894/17913 0e+00 0.0000 85
GO:2000027 regulation of animal organ morphogenesis 35/966 250/17913 0e+00 0.0000 35
GO:0043434 response to peptide hormone 48/966 404/17913 0e+00 0.0000 48
GO:0051347 positive regulation of transferase activity 64/966 609/17913 0e+00 0.0000 64
GO:0051098 regulation of binding 45/966 368/17913 0e+00 0.0000 45
GO:0071375 cellular response to peptide hormone stimulus 39/966 297/17913 0e+00 0.0000 39
GO:0006457 protein folding 28/966 176/17913 0e+00 0.0000 28
GO:0007409 axonogenesis 47/966 393/17913 0e+00 0.0000 47
GO:0009266 response to temperature stimulus 32/966 219/17913 0e+00 0.0000 32
GO:0006836 neurotransmitter transport 34/966 241/17913 0e+00 0.0000 34
GO:0030072 peptide hormone secretion 34/966 241/17913 0e+00 0.0000 34
GO:0032101 regulation of response to external stimulus 83/966 873/17913 0e+00 0.0000 83
GO:0007420 brain development 70/966 694/17913 0e+00 0.0000 70
GO:0090276 regulation of peptide hormone secretion 30/966 199/17913 0e+00 0.0000 30
GO:0009308 amine metabolic process 23/966 128/17913 0e+00 0.0000 23
GO:0006974 cellular response to DNA damage stimulus 77/966 791/17913 0e+00 0.0000 77
GO:0008015 blood circulation 57/966 523/17913 0e+00 0.0000 57
GO:0009408 response to heat 26/966 158/17913 0e+00 0.0000 26
GO:0043488 regulation of mRNA stability 26/966 158/17913 0e+00 0.0000 26
GO:0017144 drug metabolic process 77/966 792/17913 0e+00 0.0000 77
GO:0043312 neutrophil degranulation 54/966 485/17913 0e+00 0.0000 54
GO:0046879 hormone secretion 39/966 301/17913 0e+00 0.0000 39
GO:0002446 neutrophil mediated immunity 55/966 499/17913 0e+00 0.0000 55
GO:0042119 neutrophil activation 55/966 499/17913 0e+00 0.0000 55
GO:0050878 regulation of body fluid levels 55/966 499/17913 0e+00 0.0000 55
GO:0061564 axon development 50/966 438/17913 0e+00 0.0000 50
GO:0050851 antigen receptor-mediated signaling pathway 32/966 224/17913 0e+00 0.0000 32
GO:0010720 positive regulation of cell development 57/966 528/17913 0e+00 0.0000 57
GO:0044106 cellular amine metabolic process 22/966 121/17913 0e+00 0.0000 22
GO:0043408 regulation of MAPK cascade 69/966 689/17913 0e+00 0.0000 69
GO:0044706 multi-multicellular organism process 32/966 225/17913 0e+00 0.0000 32
GO:0001101 response to acid chemical 41/966 330/17913 0e+00 0.0000 41
GO:0030003 cellular cation homeostasis 56/966 518/17913 0e+00 0.0000 56
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 17/966 77/17913 0e+00 0.0000 17
GO:0003013 circulatory system process 57/966 532/17913 0e+00 0.0000 57
GO:0036230 granulocyte activation 55/966 506/17913 0e+00 0.0000 55
GO:0043269 regulation of ion transport 65/966 639/17913 0e+00 0.0000 65
GO:0043487 regulation of RNA stability 26/966 163/17913 0e+00 0.0000 26
GO:0009887 animal organ morphogenesis 90/966 989/17913 0e+00 0.0000 90
GO:0071396 cellular response to lipid 60/966 576/17913 0e+00 0.0000 60
GO:0045087 innate immune response 83/966 893/17913 0e+00 0.0000 83
GO:0009914 hormone transport 39/966 311/17913 0e+00 0.0000 39
GO:0051170 import into nucleus 22/966 125/17913 0e+00 0.0000 22
GO:0080135 regulation of cellular response to stress 70/966 713/17913 0e+00 0.0000 70
GO:0035567 non-canonical Wnt signaling pathway 24/966 145/17913 0e+00 0.0000 24
GO:0019884 antigen processing and presentation of exogenous antigen 27/966 176/17913 0e+00 0.0000 27
GO:0097190 apoptotic signaling pathway 60/966 579/17913 0e+00 0.0000 60
GO:0033365 protein localization to organelle 76/966 798/17913 0e+00 0.0000 76
GO:0002253 activation of immune response 65/966 647/17913 0e+00 0.0000 65
GO:0045860 positive regulation of protein kinase activity 54/966 501/17913 0e+00 0.0000 54
GO:0003006 developmental process involved in reproduction 65/966 649/17913 0e+00 0.0001 65
GO:0002275 myeloid cell activation involved in immune response 57/966 542/17913 0e+00 0.0001 57
GO:0002790 peptide secretion 60/966 582/17913 0e+00 0.0001 60
GO:0015696 ammonium transport 17/966 81/17913 0e+00 0.0001 17
GO:0006873 cellular ion homeostasis 56/966 531/17913 0e+00 0.0001 56
GO:0043299 leukocyte degranulation 56/966 532/17913 0e+00 0.0001 56
GO:0045597 positive regulation of cell differentiation 87/966 962/17913 0e+00 0.0001 87
GO:0050769 positive regulation of neurogenesis 50/966 455/17913 0e+00 0.0001 50
GO:0070201 regulation of establishment of protein localization 70/966 723/17913 0e+00 0.0001 70
GO:0040008 regulation of growth 66/966 668/17913 0e+00 0.0001 66
GO:0006259 DNA metabolic process 87/966 964/17913 0e+00 0.0001 87
GO:0032880 regulation of protein localization 88/966 979/17913 0e+00 0.0001 88
GO:0043549 regulation of kinase activity 76/966 808/17913 0e+00 0.0001 76
GO:0055080 cation homeostasis 60/966 588/17913 0e+00 0.0001 60
GO:0071453 cellular response to oxygen levels 32/966 237/17913 0e+00 0.0001 32
GO:0045055 regulated exocytosis 73/966 768/17913 0e+00 0.0001 73
GO:1901361 organic cyclic compound catabolic process 67/966 685/17913 0e+00 0.0001 67
GO:0007565 female pregnancy 28/966 193/17913 0e+00 0.0001 28
GO:0001819 positive regulation of cytokine production 49/966 446/17913 0e+00 0.0001 49
GO:0009991 response to extracellular stimulus 53/966 498/17913 0e+00 0.0001 53
GO:0009755 hormone-mediated signaling pathway 30/966 216/17913 0e+00 0.0001 30
GO:0009636 response to toxic substance 53/966 499/17913 0e+00 0.0001 53
GO:0051100 negative regulation of binding 25/966 162/17913 0e+00 0.0001 25
GO:0032868 response to insulin 33/966 252/17913 0e+00 0.0001 33
GO:0002478 antigen processing and presentation of exogenous peptide antigen 26/966 174/17913 0e+00 0.0001 26
GO:0009895 negative regulation of catabolic process 36/966 288/17913 0e+00 0.0001 36
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 17/966 85/17913 0e+00 0.0001 17
GO:0048608 reproductive structure development 47/966 426/17913 0e+00 0.0001 47
GO:0034655 nucleobase-containing compound catabolic process 60/966 598/17913 0e+00 0.0001 60
GO:0034976 response to endoplasmic reticulum stress 33/966 254/17913 0e+00 0.0001 33
GO:0006352 DNA-templated transcription, initiation 31/966 231/17913 0e+00 0.0001 31
GO:0019882 antigen processing and presentation 30/966 220/17913 0e+00 0.0001 30
GO:0036294 cellular response to decreased oxygen levels 30/966 220/17913 0e+00 0.0001 30
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 18/966 95/17913 0e+00 0.0001 18
GO:0031667 response to nutrient levels 50/966 466/17913 0e+00 0.0001 50
GO:0098771 inorganic ion homeostasis 60/966 600/17913 0e+00 0.0001 60
GO:0046700 heterocycle catabolic process 63/966 641/17913 0e+00 0.0001 63
GO:0071407 cellular response to organic cyclic compound 55/966 533/17913 0e+00 0.0001 55
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 39/966 328/17913 0e+00 0.0001 39
GO:0071456 cellular response to hypoxia 29/966 210/17913 0e+00 0.0001 29
GO:0061458 reproductive system development 47/966 429/17913 0e+00 0.0001 47
GO:0050767 regulation of neurogenesis 72/966 768/17913 0e+00 0.0001 72
GO:0048002 antigen processing and presentation of peptide antigen 27/966 188/17913 0e+00 0.0001 27
GO:0006521 regulation of cellular amino acid metabolic process 14/966 61/17913 0e+00 0.0001 14
GO:0002764 immune response-regulating signaling pathway 60/966 603/17913 0e+00 0.0001 60
GO:0061013 regulation of mRNA catabolic process 26/966 178/17913 0e+00 0.0001 26
GO:0034504 protein localization to nucleus 30/966 223/17913 0e+00 0.0001 30
GO:0007568 aging 38/966 318/17913 0e+00 0.0001 38
GO:0008284 positive regulation of cell proliferation 83/966 931/17913 0e+00 0.0001 83
GO:0048729 tissue morphogenesis 62/966 635/17913 0e+00 0.0001 62
GO:0016579 protein deubiquitination 33/966 260/17913 0e+00 0.0001 33
GO:0002757 immune response-activating signal transduction 57/966 567/17913 0e+00 0.0001 57
GO:0030522 intracellular receptor signaling pathway 34/966 272/17913 0e+00 0.0001 34
GO:0034612 response to tumor necrosis factor 35/966 284/17913 0e+00 0.0001 35
GO:0045859 regulation of protein kinase activity 69/966 733/17913 0e+00 0.0001 69
GO:0048863 stem cell differentiation 31/966 237/17913 0e+00 0.0002 31
GO:0001505 regulation of neurotransmitter levels 38/966 321/17913 0e+00 0.0002 38
GO:0070646 protein modification by small protein removal 34/966 273/17913 0e+00 0.0002 34
GO:0002274 myeloid leukocyte activation 63/966 652/17913 0e+00 0.0002 63
GO:0031175 neuron projection development 79/966 879/17913 0e+00 0.0002 79
GO:0042593 glucose homeostasis 30/966 227/17913 0e+00 0.0002 30
GO:0008285 negative regulation of cell proliferation 70/966 751/17913 0e+00 0.0002 70
GO:1902036 regulation of hematopoietic stem cell differentiation 15/966 72/17913 0e+00 0.0002 15
GO:0031145 anaphase-promoting complex-dependent catabolic process 16/966 81/17913 0e+00 0.0002 16
GO:0033500 carbohydrate homeostasis 30/966 228/17913 0e+00 0.0002 30
GO:0032386 regulation of intracellular transport 44/966 400/17913 0e+00 0.0002 44
GO:0019439 aromatic compound catabolic process 63/966 655/17913 0e+00 0.0002 63
GO:0044270 cellular nitrogen compound catabolic process 62/966 642/17913 0e+00 0.0002 62
GO:0099536 synaptic signaling 59/966 601/17913 0e+00 0.0002 59
GO:0060627 regulation of vesicle-mediated transport 50/966 480/17913 0e+00 0.0002 50
GO:0006875 cellular metal ion homeostasis 49/966 467/17913 0e+00 0.0002 49
GO:0001944 vasculature development 72/966 784/17913 0e+00 0.0002 72
GO:0030163 protein catabolic process 73/966 799/17913 0e+00 0.0002 73
GO:0002443 leukocyte mediated immunity 74/966 814/17913 0e+00 0.0002 74
GO:0051090 regulation of DNA-binding transcription factor activity 46/966 429/17913 0e+00 0.0002 46
GO:0001525 angiogenesis 57/966 576/17913 0e+00 0.0002 57
GO:0043270 positive regulation of ion transport 33/966 266/17913 0e+00 0.0002 33
GO:0071356 cellular response to tumor necrosis factor 33/966 266/17913 0e+00 0.0002 33
GO:0000904 cell morphogenesis involved in differentiation 61/966 632/17913 0e+00 0.0002 61
GO:0002791 regulation of peptide secretion 50/966 483/17913 0e+00 0.0002 50
GO:0000902 cell morphogenesis 78/966 874/17913 0e+00 0.0002 78
GO:0032869 cellular response to insulin stimulus 27/966 197/17913 0e+00 0.0002 27
GO:0060218 hematopoietic stem cell differentiation 16/966 83/17913 0e+00 0.0002 16
GO:0032735 positive regulation of interleukin-12 production 10/966 34/17913 0e+00 0.0002 10
GO:0051223 regulation of protein transport 64/966 677/17913 0e+00 0.0002 64
GO:0045333 cellular respiration 25/966 176/17913 0e+00 0.0003 25
GO:0019373 epoxygenase P450 pathway 6/966 11/17913 0e+00 0.0003 6
GO:0060284 regulation of cell development 79/966 893/17913 0e+00 0.0003 79
GO:0072358 cardiovascular system development 72/966 792/17913 0e+00 0.0003 72
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 15/966 75/17913 0e+00 0.0003 15
GO:0045664 regulation of neuron differentiation 59/966 609/17913 0e+00 0.0003 59
GO:0048667 cell morphogenesis involved in neuron differentiation 51/966 500/17913 0e+00 0.0003 51
GO:0010498 proteasomal protein catabolic process 42/966 382/17913 0e+00 0.0003 42
GO:0010948 negative regulation of cell cycle process 39/966 344/17913 0e+00 0.0003 39
GO:0051047 positive regulation of secretion 44/966 409/17913 0e+00 0.0003 44
GO:0030073 insulin secretion 27/966 200/17913 0e+00 0.0003 27
GO:1901532 regulation of hematopoietic progenitor cell differentiation 16/966 85/17913 0e+00 0.0003 16
GO:0033209 tumor necrosis factor-mediated signaling pathway 24/966 167/17913 0e+00 0.0003 24
GO:0098810 neurotransmitter reuptake 8/966 22/17913 0e+00 0.0003 8
GO:0045786 negative regulation of cell cycle 59/966 613/17913 0e+00 0.0003 59
GO:0050801 ion homeostasis 63/966 669/17913 0e+00 0.0003 63
GO:0055065 metal ion homeostasis 53/966 531/17913 0e+00 0.0003 53
GO:0006520 cellular amino acid metabolic process 39/966 347/17913 0e+00 0.0003 39
GO:0048514 blood vessel morphogenesis 63/966 670/17913 0e+00 0.0003 63
GO:0048013 ephrin receptor signaling pathway 16/966 86/17913 0e+00 0.0003 16
GO:0009615 response to virus 37/966 323/17913 0e+00 0.0003 37
GO:0009060 aerobic respiration 14/966 68/17913 0e+00 0.0003 14
GO:0030001 metal ion transport 72/966 800/17913 0e+00 0.0003 72
GO:0043902 positive regulation of multi-organism process 25/966 180/17913 0e+00 0.0003 25
GO:0038095 Fc-epsilon receptor signaling pathway 24/966 169/17913 0e+00 0.0003 24
GO:0051338 regulation of transferase activity 79/966 903/17913 0e+00 0.0003 79
GO:0046794 transport of virus 13/966 60/17913 0e+00 0.0004 13
GO:1903706 regulation of hemopoiesis 48/966 468/17913 0e+00 0.0004 48
GO:0035239 tube morphogenesis 79/966 905/17913 0e+00 0.0004 79
GO:0045471 response to ethanol 20/966 127/17913 0e+00 0.0004 20
GO:0007268 chemical synaptic transmission 57/966 591/17913 0e+00 0.0004 57
GO:0098916 anterograde trans-synaptic signaling 57/966 591/17913 0e+00 0.0004 57
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 15/966 78/17913 0e+00 0.0004 15
GO:1902750 negative regulation of cell cycle G2/M phase transition 17/966 97/17913 0e+00 0.0004 17
GO:0006935 chemotaxis 54/966 551/17913 0e+00 0.0004 54
GO:0035821 modification of morphology or physiology of other organism 23/966 160/17913 0e+00 0.0004 23
GO:0043393 regulation of protein binding 28/966 217/17913 0e+00 0.0004 28
GO:0009607 response to biotic stimulus 81/966 938/17913 0e+00 0.0004 81
GO:0070555 response to interleukin-1 25/966 183/17913 0e+00 0.0004 25
GO:0072503 cellular divalent inorganic cation homeostasis 42/966 392/17913 0e+00 0.0004 42
GO:0042330 taxis 54/966 553/17913 0e+00 0.0004 54
GO:0043410 positive regulation of MAPK cascade 50/966 499/17913 0e+00 0.0004 50
GO:0001816 cytokine production 69/966 765/17913 0e+00 0.0004 69
GO:0001568 blood vessel development 68/966 751/17913 0e+00 0.0004 68
GO:0099537 trans-synaptic signaling 57/966 596/17913 0e+00 0.0004 57
GO:0006401 RNA catabolic process 40/966 368/17913 0e+00 0.0005 40
GO:1903532 positive regulation of secretion by cell 41/966 381/17913 0e+00 0.0005 41
GO:0002768 immune response-regulating cell surface receptor signaling pathway 45/966 434/17913 0e+00 0.0005 45
GO:0006936 muscle contraction 38/966 343/17913 0e+00 0.0005 38
GO:0051960 regulation of nervous system development 76/966 870/17913 0e+00 0.0005 76
GO:0006091 generation of precursor metabolites and energy 50/966 502/17913 0e+00 0.0005 50
GO:0051952 regulation of amine transport 14/966 71/17913 0e+00 0.0005 14
GO:0097305 response to alcohol 29/966 232/17913 0e+00 0.0005 29
GO:0031330 negative regulation of cellular catabolic process 30/966 244/17913 0e+00 0.0005 30
GO:0006954 inflammatory response 70/966 784/17913 0e+00 0.0005 70
GO:0001817 regulation of cytokine production 64/966 698/17913 0e+00 0.0005 64
GO:0007548 sex differentiation 32/966 269/17913 0e+00 0.0005 32
GO:0019226 transmission of nerve impulse 12/966 54/17913 0e+00 0.0005 12
GO:0015672 monovalent inorganic cation transport 48/966 477/17913 0e+00 0.0005 48
GO:0051707 response to other organism 78/966 903/17913 0e+00 0.0005 78
GO:0040007 growth 81/966 948/17913 0e+00 0.0005 81
GO:0051962 positive regulation of nervous system development 51/966 519/17913 0e+00 0.0006 51
GO:0043207 response to external biotic stimulus 78/966 905/17913 0e+00 0.0006 78
GO:0072507 divalent inorganic cation homeostasis 43/966 412/17913 0e+00 0.0006 43
GO:0072594 establishment of protein localization to organelle 46/966 452/17913 0e+00 0.0006 46
GO:0002429 immune response-activating cell surface receptor signaling pathway 42/966 399/17913 0e+00 0.0006 42
GO:0032615 interleukin-12 production 12/966 55/17913 0e+00 0.0006 12
GO:0009306 protein secretion 53/966 549/17913 0e+00 0.0006 53
GO:0043632 modification-dependent macromolecule catabolic process 51/966 522/17913 0e+00 0.0006 51
GO:0009743 response to carbohydrate 28/966 224/17913 0e+00 0.0006 28
GO:0044766 multi-organism transport 14/966 73/17913 0e+00 0.0006 14
GO:1902579 multi-organism localization 14/966 73/17913 0e+00 0.0006 14
GO:0001504 neurotransmitter uptake 10/966 39/17913 0e+00 0.0006 10
GO:0044257 cellular protein catabolic process 60/966 648/17913 0e+00 0.0006 60
GO:0006367 transcription initiation from RNA polymerase II promoter 24/966 178/17913 0e+00 0.0007 24
GO:0071347 cellular response to interleukin-1 22/966 156/17913 0e+00 0.0007 22
GO:0044057 regulation of system process 56/966 594/17913 0e+00 0.0007 56
GO:0006606 protein import into nucleus 17/966 103/17913 0e+00 0.0007 17
GO:0048524 positive regulation of viral process 17/966 103/17913 0e+00 0.0007 17
GO:0031347 regulation of defense response 76/966 885/17913 0e+00 0.0008 76
GO:0002009 morphogenesis of an epithelium 51/966 527/17913 0e+00 0.0008 51
GO:0015980 energy derivation by oxidation of organic compounds 31/966 264/17913 0e+00 0.0008 31
GO:0050796 regulation of insulin secretion 23/966 169/17913 0e+00 0.0008 23
GO:0048024 regulation of mRNA splicing, via spliceosome 14/966 75/17913 0e+00 0.0008 14
GO:0046677 response to antibiotic 36/966 328/17913 0e+00 0.0008 36
GO:0075733 intracellular transport of virus 12/966 57/17913 0e+00 0.0008 12
GO:0002366 leukocyte activation involved in immune response 62/966 684/17913 0e+00 0.0008 62
GO:0043484 regulation of RNA splicing 18/966 115/17913 0e+00 0.0008 18
GO:0006281 DNA repair 49/966 502/17913 0e+00 0.0009 49
GO:0038093 Fc receptor signaling pathway 29/966 241/17913 0e+00 0.0009 29
GO:0051954 positive regulation of amine transport 9/966 33/17913 0e+00 0.0009 9
GO:0045666 positive regulation of neuron differentiation 38/966 355/17913 0e+00 0.0009 38
GO:0050770 regulation of axonogenesis 21/966 148/17913 0e+00 0.0009 21
GO:2000736 regulation of stem cell differentiation 18/966 116/17913 0e+00 0.0009 18
GO:0015837 amine transport 14/966 76/17913 0e+00 0.0009 14
GO:0034622 cellular protein-containing complex assembly 80/966 952/17913 0e+00 0.0010 80
GO:0002263 cell activation involved in immune response 62/966 688/17913 0e+00 0.0010 62
GO:0071383 cellular response to steroid hormone stimulus 29/966 243/17913 1e-04 0.0010 29
GO:2001233 regulation of apoptotic signaling pathway 41/966 397/17913 1e-04 0.0010 41
GO:0018105 peptidyl-serine phosphorylation 28/966 231/17913 1e-04 0.0010 28
GO:0006897 endocytosis 61/966 675/17913 1e-04 0.0010 61
GO:0034605 cellular response to heat 18/966 117/17913 1e-04 0.0010 18
GO:0030099 myeloid cell differentiation 42/966 411/17913 1e-04 0.0010 42
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 17/966 107/17913 1e-04 0.0011 17
GO:0006403 RNA localization 26/966 208/17913 1e-04 0.0011 26
GO:0062012 regulation of small molecule metabolic process 44/966 439/17913 1e-04 0.0011 44
GO:0000122 negative regulation of transcription by RNA polymerase II 65/966 735/17913 1e-04 0.0011 65
GO:0051091 positive regulation of DNA-binding transcription factor activity 30/966 257/17913 1e-04 0.0011 30
GO:0010389 regulation of G2/M transition of mitotic cell cycle 24/966 185/17913 1e-04 0.0011 24
GO:0098660 inorganic ion transmembrane transport 64/966 722/17913 1e-04 0.0011 64
GO:0051588 regulation of neurotransmitter transport 19/966 129/17913 1e-04 0.0011 19
GO:0050684 regulation of mRNA processing 17/966 108/17913 1e-04 0.0012 17
GO:0006511 ubiquitin-dependent protein catabolic process 49/966 510/17913 1e-04 0.0012 49
GO:0043405 regulation of MAP kinase activity 35/966 322/17913 1e-04 0.0012 35
GO:0032989 cellular component morphogenesis 80/966 960/17913 1e-04 0.0012 80
GO:0055074 calcium ion homeostasis 40/966 388/17913 1e-04 0.0012 40
GO:0006874 cellular calcium ion homeostasis 39/966 375/17913 1e-04 0.0012 39
GO:0043065 positive regulation of apoptotic process 59/966 652/17913 1e-04 0.0012 59
GO:0035690 cellular response to drug 38/966 362/17913 1e-04 0.0012 38
GO:1903312 negative regulation of mRNA metabolic process 13/966 69/17913 1e-04 0.0013 13
GO:0022407 regulation of cell-cell adhesion 40/966 389/17913 1e-04 0.0013 40
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 55/966 596/17913 1e-04 0.0013 55
GO:0017157 regulation of exocytosis 24/966 187/17913 1e-04 0.0013 24
GO:0090175 regulation of establishment of planar polarity 17/966 109/17913 1e-04 0.0013 17
GO:0002064 epithelial cell development 25/966 199/17913 1e-04 0.0013 25
GO:0006937 regulation of muscle contraction 22/966 164/17913 1e-04 0.0013 22
GO:0051052 regulation of DNA metabolic process 41/966 403/17913 1e-04 0.0013 41
GO:0051101 regulation of DNA binding 18/966 120/17913 1e-04 0.0013 18
GO:0044703 multi-organism reproductive process 81/966 980/17913 1e-04 0.0014 81
GO:0006402 mRNA catabolic process 36/966 338/17913 1e-04 0.0014 36
GO:0034284 response to monosaccharide 25/966 200/17913 1e-04 0.0014 25
GO:0042098 T cell proliferation 23/966 177/17913 1e-04 0.0014 23
GO:0008361 regulation of cell size 21/966 154/17913 1e-04 0.0014 21
GO:0019941 modification-dependent protein catabolic process 49/966 515/17913 1e-04 0.0014 49
GO:0030100 regulation of endocytosis 30/966 262/17913 1e-04 0.0014 30
GO:0006470 protein dephosphorylation 34/966 313/17913 1e-04 0.0014 34
GO:0002886 regulation of myeloid leukocyte mediated immunity 11/966 52/17913 1e-04 0.0014 11
GO:0002573 myeloid leukocyte differentiation 25/966 201/17913 1e-04 0.0014 25
GO:0007623 circadian rhythm 25/966 201/17913 1e-04 0.0014 25
GO:0050804 modulation of chemical synaptic transmission 40/966 393/17913 1e-04 0.0015 40
GO:0000086 G2/M transition of mitotic cell cycle 28/966 238/17913 1e-04 0.0015 28
GO:0045165 cell fate commitment 28/966 238/17913 1e-04 0.0015 28
GO:0120039 plasma membrane bounded cell projection morphogenesis 53/966 573/17913 1e-04 0.0015 53
GO:0048812 neuron projection morphogenesis 52/966 559/17913 1e-04 0.0015 52
GO:0010817 regulation of hormone levels 48/966 503/17913 1e-04 0.0015 48
GO:0003012 muscle system process 44/966 448/17913 1e-04 0.0015 44
GO:0051656 establishment of organelle localization 44/966 448/17913 1e-04 0.0015 44
GO:0060560 developmental growth involved in morphogenesis 26/966 214/17913 1e-04 0.0015 26
GO:0099177 regulation of trans-synaptic signaling 40/966 394/17913 1e-04 0.0015 40
GO:0071363 cellular response to growth factor stimulus 60/966 674/17913 1e-04 0.0015 60
GO:0043068 positive regulation of programmed cell death 59/966 660/17913 1e-04 0.0016 59
GO:0030162 regulation of proteolysis 66/966 762/17913 1e-04 0.0016 66
GO:0043900 regulation of multi-organism process 41/966 408/17913 1e-04 0.0016 41
GO:0018209 peptidyl-serine modification 29/966 252/17913 1e-04 0.0016 29
GO:0007584 response to nutrient 26/966 215/17913 1e-04 0.0016 26
GO:0032147 activation of protein kinase activity 33/966 303/17913 1e-04 0.0016 33
GO:0032655 regulation of interleukin-12 production 11/966 53/17913 1e-04 0.0016 11
GO:0010976 positive regulation of neuron projection development 30/966 265/17913 1e-04 0.0016 30
GO:0001736 establishment of planar polarity 18/966 123/17913 1e-04 0.0017 18
GO:0007164 establishment of tissue polarity 18/966 123/17913 1e-04 0.0017 18
GO:0015850 organic hydroxy compound transport 27/966 228/17913 1e-04 0.0017 27
GO:0051650 establishment of vesicle localization 29/966 253/17913 1e-04 0.0017 29
GO:0048858 cell projection morphogenesis 53/966 577/17913 1e-04 0.0017 53
GO:0002888 positive regulation of myeloid leukocyte mediated immunity 8/966 29/17913 1e-04 0.0017 8
GO:0071900 regulation of protein serine/threonine kinase activity 46/966 479/17913 1e-04 0.0017 46
GO:0051651 maintenance of location in cell 13/966 72/17913 1e-04 0.0017 13
GO:0007610 behavior 53/966 578/17913 1e-04 0.0018 53
GO:0045921 positive regulation of exocytosis 14/966 82/17913 1e-04 0.0018 14
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 17/966 113/17913 1e-04 0.0018 17
GO:0050900 leukocyte migration 45/966 467/17913 1e-04 0.0019 45
GO:0045088 regulation of innate immune response 43/966 440/17913 1e-04 0.0019 43
GO:0010942 positive regulation of cell death 62/966 710/17913 1e-04 0.0019 62
GO:0060249 anatomical structure homeostasis 41/966 413/17913 1e-04 0.0019 41
GO:0032990 cell part morphogenesis 54/966 595/17913 1e-04 0.0019 54
GO:0046887 positive regulation of hormone secretion 18/966 125/17913 1e-04 0.0020 18
GO:0019932 second-messenger-mediated signaling 37/966 360/17913 1e-04 0.0020 37
GO:0070997 neuron death 36/966 347/17913 1e-04 0.0020 36
GO:1901990 regulation of mitotic cell cycle phase transition 42/966 428/17913 1e-04 0.0020 42
GO:0045926 negative regulation of growth 28/966 244/17913 1e-04 0.0021 28
GO:1902600 proton transmembrane transport 20/966 148/17913 1e-04 0.0021 20
GO:0098586 cellular response to virus 11/966 55/17913 1e-04 0.0022 11
GO:0051272 positive regulation of cellular component movement 51/966 555/17913 1e-04 0.0022 51
GO:0009790 embryo development 79/966 968/17913 1e-04 0.0022 79
GO:0071902 positive regulation of protein serine/threonine kinase activity 34/966 322/17913 1e-04 0.0022 34
GO:0002521 leukocyte differentiation 46/966 485/17913 1e-04 0.0022 46
GO:0016572 histone phosphorylation 9/966 38/17913 1e-04 0.0022 9
GO:0071214 cellular response to abiotic stimulus 33/966 310/17913 2e-04 0.0023 33
GO:0104004 cellular response to environmental stimulus 33/966 310/17913 2e-04 0.0023 33
GO:0098662 inorganic cation transmembrane transport 57/966 643/17913 2e-04 0.0023 57
GO:0007569 cell aging 17/966 116/17913 2e-04 0.0023 17
GO:0030155 regulation of cell adhesion 58/966 659/17913 2e-04 0.0024 58
GO:0002758 innate immune response-activating signal transduction 32/966 298/17913 2e-04 0.0024 32
GO:0045137 development of primary sexual characteristics 26/966 223/17913 2e-04 0.0026 26
GO:0018279 protein N-linked glycosylation via asparagine 8/966 31/17913 2e-04 0.0026 8
GO:0015844 monoamine transport 12/966 66/17913 2e-04 0.0027 12
GO:0051603 proteolysis involved in cellular protein catabolic process 53/966 590/17913 2e-04 0.0027 53
GO:0032392 DNA geometric change 14/966 86/17913 2e-04 0.0028 14
GO:0010506 regulation of autophagy 33/966 314/17913 2e-04 0.0028 33
GO:0060047 heart contraction 30/966 275/17913 2e-04 0.0028 30
GO:0032890 regulation of organic acid transport 11/966 57/17913 2e-04 0.0029 11
GO:0033119 negative regulation of RNA splicing 7/966 24/17913 2e-04 0.0029 7
GO:0043406 positive regulation of MAP kinase activity 28/966 250/17913 2e-04 0.0029 28
GO:0001889 liver development 18/966 130/17913 2e-04 0.0030 18
GO:0046683 response to organophosphorus 18/966 130/17913 2e-04 0.0030 18
GO:0090257 regulation of muscle system process 28/966 251/17913 2e-04 0.0031 28
GO:0044772 mitotic cell cycle phase transition 51/966 565/17913 2e-04 0.0031 51
GO:0048598 embryonic morphogenesis 51/966 565/17913 2e-04 0.0031 51
GO:0042987 amyloid precursor protein catabolic process 9/966 40/17913 2e-04 0.0032 9
GO:0097193 intrinsic apoptotic signaling pathway 30/966 277/17913 2e-04 0.0032 30
GO:0001678 cellular glucose homeostasis 19/966 142/17913 2e-04 0.0032 19
GO:0018196 peptidyl-asparagine modification 8/966 32/17913 2e-04 0.0032 8
GO:1903047 mitotic cell cycle process 68/966 816/17913 2e-04 0.0032 68
GO:0034762 regulation of transmembrane transport 49/966 538/17913 2e-04 0.0033 49
GO:1902749 regulation of cell cycle G2/M phase transition 24/966 202/17913 2e-04 0.0033 24
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 22/966 178/17913 2e-04 0.0034 22
GO:0007369 gastrulation 22/966 178/17913 2e-04 0.0034 22
GO:0039535 regulation of RIG-I signaling pathway 6/966 18/17913 3e-04 0.0035 6
GO:0046641 positive regulation of alpha-beta T cell proliferation 6/966 18/17913 3e-04 0.0035 6
GO:0038061 NIK/NF-kappaB signaling 22/966 179/17913 3e-04 0.0036 22
GO:0051236 establishment of RNA localization 22/966 179/17913 3e-04 0.0036 22
GO:0002218 activation of innate immune response 33/966 319/17913 3e-04 0.0036 33
GO:0048872 homeostasis of number of cells 27/966 241/17913 3e-04 0.0036 27
GO:0015991 ATP hydrolysis coupled proton transport 7/966 25/17913 3e-04 0.0036 7
GO:0018108 peptidyl-tyrosine phosphorylation 35/966 346/17913 3e-04 0.0036 35
GO:0043062 extracellular structure organization 38/966 387/17913 3e-04 0.0037 38
GO:0050434 positive regulation of viral transcription 9/966 41/17913 3e-04 0.0037 9
GO:0042391 regulation of membrane potential 37/966 374/17913 3e-04 0.0038 37
GO:0061008 hepaticobiliary system development 18/966 133/17913 3e-04 0.0038 18
GO:0008406 gonad development 25/966 217/17913 3e-04 0.0038 25
GO:0032892 positive regulation of organic acid transport 8/966 33/17913 3e-04 0.0039 8
GO:0006353 DNA-templated transcription, termination 12/966 69/17913 3e-04 0.0039 12
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 12/966 69/17913 3e-04 0.0039 12
GO:0046822 regulation of nucleocytoplasmic transport 15/966 100/17913 3e-04 0.0039 15
GO:0006405 RNA export from nucleus 17/966 122/17913 3e-04 0.0039 17
GO:0010975 regulation of neuron projection development 43/966 458/17913 3e-04 0.0039 43
GO:0070848 response to growth factor 60/966 704/17913 3e-04 0.0040 60
GO:0031346 positive regulation of cell projection organization 36/966 362/17913 3e-04 0.0040 36
GO:0010564 regulation of cell cycle process 64/966 764/17913 3e-04 0.0040 64
GO:0043401 steroid hormone mediated signaling pathway 22/966 181/17913 3e-04 0.0040 22
GO:0051099 positive regulation of binding 22/966 181/17913 3e-04 0.0040 22
GO:0061387 regulation of extent of cell growth 14/966 90/17913 3e-04 0.0041 14
GO:0018212 peptidyl-tyrosine modification 35/966 349/17913 3e-04 0.0041 35
GO:0010469 regulation of signaling receptor activity 52/966 588/17913 3e-04 0.0041 52
GO:0007599 hemostasis 34/966 336/17913 3e-04 0.0042 34
GO:0032479 regulation of type I interferon production 17/966 123/17913 3e-04 0.0042 17
GO:0044839 cell cycle G2/M phase transition 28/966 257/17913 3e-04 0.0042 28
GO:0009410 response to xenobiotic stimulus 29/966 270/17913 3e-04 0.0042 29
GO:0051648 vesicle localization 29/966 270/17913 3e-04 0.0042 29
GO:0048675 axon extension 15/966 101/17913 3e-04 0.0042 15
GO:0002244 hematopoietic progenitor cell differentiation 20/966 158/17913 3e-04 0.0043 20
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 26/966 232/17913 3e-04 0.0043 26
GO:0050817 coagulation 34/966 337/17913 3e-04 0.0043 34
GO:0003015 heart process 30/966 284/17913 3e-04 0.0044 30
GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient 7/966 26/17913 3e-04 0.0044 7
GO:0009746 response to hexose 23/966 195/17913 4e-04 0.0044 23
GO:0010959 regulation of metal ion transport 36/966 365/17913 4e-04 0.0045 36
GO:0042177 negative regulation of protein catabolic process 17/966 124/17913 4e-04 0.0045 17
GO:0048025 negative regulation of mRNA splicing, via spliceosome 6/966 19/17913 4e-04 0.0045 6
GO:1990182 exosomal secretion 6/966 19/17913 4e-04 0.0045 6
GO:0002223 stimulatory C-type lectin receptor signaling pathway 16/966 113/17913 4e-04 0.0046 16
GO:0048645 animal organ formation 11/966 61/17913 4e-04 0.0046 11
GO:0015931 nucleobase-containing compound transport 25/966 221/17913 4e-04 0.0047 25
GO:0007346 regulation of mitotic cell cycle 54/966 622/17913 4e-04 0.0047 54
GO:1901987 regulation of cell cycle phase transition 43/966 464/17913 4e-04 0.0048 43
GO:0051235 maintenance of location 30/966 286/17913 4e-04 0.0048 30
GO:0032606 type I interferon production 17/966 125/17913 4e-04 0.0048 17
GO:0042060 wound healing 49/966 550/17913 4e-04 0.0048 49
GO:1904646 cellular response to amyloid-beta 9/966 43/17913 4e-04 0.0049 9
GO:0032091 negative regulation of protein binding 15/966 103/17913 4e-04 0.0050 15
GO:0044770 cell cycle phase transition 53/966 609/17913 4e-04 0.0050 53
GO:0043254 regulation of protein complex assembly 39/966 409/17913 4e-04 0.0050 39
GO:0042176 regulation of protein catabolic process 35/966 354/17913 4e-04 0.0050 35
GO:0046034 ATP metabolic process 30/966 287/17913 4e-04 0.0050 30
GO:1901991 negative regulation of mitotic cell cycle phase transition 26/966 235/17913 4e-04 0.0050 26
GO:0006970 response to osmotic stress 13/966 82/17913 4e-04 0.0051 13
GO:0046777 protein autophosphorylation 24/966 210/17913 4e-04 0.0051 24
GO:0042129 regulation of T cell proliferation 19/966 149/17913 4e-04 0.0051 19
GO:0016049 cell growth 43/966 466/17913 4e-04 0.0051 43
GO:0050772 positive regulation of axonogenesis 12/966 72/17913 4e-04 0.0052 12
GO:0051591 response to cAMP 14/966 93/17913 4e-04 0.0053 14
GO:0050686 negative regulation of mRNA processing 7/966 27/17913 4e-04 0.0053 7
GO:0099131 ATP hydrolysis coupled ion transmembrane transport 7/966 27/17913 4e-04 0.0053 7
GO:0098655 cation transmembrane transport 61/966 730/17913 4e-04 0.0053 61
GO:0099003 vesicle-mediated transport in synapse 21/966 174/17913 5e-04 0.0055 21
GO:0070838 divalent metal ion transport 42/966 454/17913 5e-04 0.0056 42
GO:0034764 positive regulation of transmembrane transport 23/966 199/17913 5e-04 0.0056 23
GO:0050670 regulation of lymphocyte proliferation 23/966 199/17913 5e-04 0.0056 23
GO:2000147 positive regulation of cell motility 48/966 540/17913 5e-04 0.0056 48
GO:0034383 low-density lipoprotein particle clearance 9/966 44/17913 5e-04 0.0056 9
GO:0039529 RIG-I signaling pathway 6/966 20/17913 5e-04 0.0057 6
GO:0042053 regulation of dopamine metabolic process 6/966 20/17913 5e-04 0.0057 6
GO:0042069 regulation of catecholamine metabolic process 6/966 20/17913 5e-04 0.0057 6
GO:0097734 extracellular exosome biogenesis 6/966 20/17913 5e-04 0.0057 6
GO:0002220 innate immune response activating cell surface receptor signaling pathway 16/966 116/17913 5e-04 0.0057 16
GO:0071426 ribonucleoprotein complex export from nucleus 16/966 116/17913 5e-04 0.0057 16
GO:0051129 negative regulation of cellular component organization 57/966 673/17913 5e-04 0.0057 57
GO:0001738 morphogenesis of a polarized epithelium 18/966 139/17913 5e-04 0.0057 18
GO:0071322 cellular response to carbohydrate stimulus 18/966 139/17913 5e-04 0.0057 18
GO:0002697 regulation of immune effector process 41/966 441/17913 5e-04 0.0057 41
GO:2001236 regulation of extrinsic apoptotic signaling pathway 19/966 151/17913 5e-04 0.0057 19
GO:0006611 protein export from nucleus 20/966 163/17913 5e-04 0.0057 20
GO:0051402 neuron apoptotic process 26/966 238/17913 5e-04 0.0057 26
GO:0072331 signal transduction by p53 class mediator 28/966 264/17913 5e-04 0.0057 28
GO:0032944 regulation of mononuclear cell proliferation 23/966 200/17913 5e-04 0.0058 23
GO:0007596 blood coagulation 33/966 331/17913 5e-04 0.0058 33
GO:0050708 regulation of protein secretion 42/966 456/17913 5e-04 0.0058 42
GO:0046649 lymphocyte activation 54/966 630/17913 5e-04 0.0059 54
GO:0008286 insulin receptor signaling pathway 17/966 128/17913 5e-04 0.0059 17
GO:0006914 autophagy 43/966 471/17913 5e-04 0.0060 43
GO:0061919 process utilizing autophagic mechanism 43/966 471/17913 5e-04 0.0060 43
GO:0050657 nucleic acid transport 21/966 176/17913 5e-04 0.0060 21
GO:0050658 RNA transport 21/966 176/17913 5e-04 0.0060 21
GO:0051168 nuclear export 21/966 176/17913 5e-04 0.0060 21
GO:0045089 positive regulation of innate immune response 36/966 373/17913 5e-04 0.0060 36
GO:0017038 protein import 18/966 140/17913 5e-04 0.0060 18
GO:0042110 T cell activation 41/966 443/17913 5e-04 0.0060 41
GO:0071166 ribonucleoprotein complex localization 16/966 117/17913 5e-04 0.0060 16
GO:1900180 regulation of protein localization to nucleus 16/966 117/17913 5e-04 0.0060 16
GO:2001020 regulation of response to DNA damage stimulus 23/966 201/17913 5e-04 0.0060 23
GO:1904645 response to amyloid-beta 10/966 54/17913 5e-04 0.0060 10
GO:0006354 DNA-templated transcription, elongation 15/966 106/17913 6e-04 0.0061 15
GO:0043200 response to amino acid 15/966 106/17913 6e-04 0.0061 15
GO:0070663 regulation of leukocyte proliferation 24/966 214/17913 6e-04 0.0061 24
GO:0016311 dephosphorylation 42/966 458/17913 6e-04 0.0061 42
GO:0072511 divalent inorganic cation transport 42/966 458/17913 6e-04 0.0061 42
GO:0030104 water homeostasis 12/966 74/17913 6e-04 0.0061 12
GO:0032481 positive regulation of type I interferon production 12/966 74/17913 6e-04 0.0061 12
GO:0090662 ATP hydrolysis coupled transmembrane transport 7/966 28/17913 6e-04 0.0062 7
GO:0010463 mesenchymal cell proliferation 9/966 45/17913 6e-04 0.0062 9
GO:0046782 regulation of viral transcription 11/966 64/17913 6e-04 0.0062 11
GO:2000145 regulation of cell motility 76/966 966/17913 6e-04 0.0062 76
GO:0009749 response to glucose 22/966 190/17913 6e-04 0.0065 22
GO:0022037 metencephalon development 15/966 107/17913 6e-04 0.0066 15
GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 6/966 21/17913 7e-04 0.0070 6
GO:0003009 skeletal muscle contraction 8/966 37/17913 7e-04 0.0071 8
GO:0051590 positive regulation of neurotransmitter transport 8/966 37/17913 7e-04 0.0071 8
GO:0050792 regulation of viral process 23/966 204/17913 7e-04 0.0072 23
GO:1901796 regulation of signal transduction by p53 class mediator 21/966 179/17913 7e-04 0.0072 21
GO:0071326 cellular response to monosaccharide stimulus 17/966 131/17913 7e-04 0.0073 17
GO:0061136 regulation of proteasomal protein catabolic process 20/966 167/17913 7e-04 0.0073 20
GO:0009314 response to radiation 40/966 435/17913 7e-04 0.0076 40
GO:0034205 amyloid-beta formation 7/966 29/17913 7e-04 0.0076 7
GO:0070661 leukocyte proliferation 28/966 270/17913 7e-04 0.0076 28
GO:0032508 DNA duplex unwinding 12/966 76/17913 7e-04 0.0076 12
GO:0019058 viral life cycle 32/966 324/17913 7e-04 0.0076 32
GO:0046651 lymphocyte proliferation 26/966 244/17913 7e-04 0.0077 26
GO:0051924 regulation of calcium ion transport 26/966 244/17913 7e-04 0.0077 26
GO:0033044 regulation of chromosome organization 31/966 311/17913 7e-04 0.0078 31
GO:0050727 regulation of inflammatory response 43/966 479/17913 7e-04 0.0078 43
GO:0021549 cerebellum development 14/966 98/17913 8e-04 0.0080 14
GO:0048638 regulation of developmental growth 32/966 325/17913 8e-04 0.0080 32
GO:1903827 regulation of cellular protein localization 45/966 509/17913 8e-04 0.0082 45
GO:0008217 regulation of blood pressure 20/966 169/17913 8e-04 0.0083 20
GO:0060401 cytosolic calcium ion transport 19/966 157/17913 8e-04 0.0084 19
GO:0002262 myeloid cell homeostasis 18/966 145/17913 8e-04 0.0084 18
GO:0014074 response to purine-containing compound 18/966 145/17913 8e-04 0.0084 18
GO:0060402 calcium ion transport into cytosol 18/966 145/17913 8e-04 0.0084 18
GO:0032943 mononuclear cell proliferation 26/966 246/17913 8e-04 0.0085 26
GO:0001558 regulation of cell growth 37/966 396/17913 8e-04 0.0085 37
GO:1903708 positive regulation of hemopoiesis 21/966 182/17913 8e-04 0.0086 21
GO:0019430 removal of superoxide radicals 6/966 22/17913 9e-04 0.0087 6
GO:0043302 positive regulation of leukocyte degranulation 6/966 22/17913 9e-04 0.0087 6
GO:0140112 extracellular vesicle biogenesis 6/966 22/17913 9e-04 0.0087 6
GO:0097529 myeloid leukocyte migration 20/966 170/17913 9e-04 0.0087 20
GO:0055067 monovalent inorganic cation homeostasis 16/966 122/17913 9e-04 0.0087 16
GO:0017014 protein nitrosylation 5/966 15/17913 9e-04 0.0087 5
GO:0018119 peptidyl-cysteine S-nitrosylation 5/966 15/17913 9e-04 0.0087 5
GO:0010769 regulation of cell morphogenesis involved in differentiation 27/966 260/17913 9e-04 0.0088 27
GO:0040017 positive regulation of locomotion 49/966 570/17913 9e-04 0.0088 49
GO:0000278 mitotic cell cycle 73/966 934/17913 9e-04 0.0089 73
GO:0031349 positive regulation of defense response 45/966 512/17913 9e-04 0.0089 45
GO:0051028 mRNA transport 18/966 146/17913 9e-04 0.0089 18
GO:0016055 Wnt signaling pathway 44/966 498/17913 9e-04 0.0091 44
GO:0052547 regulation of peptidase activity 37/966 398/17913 9e-04 0.0091 37
GO:0032760 positive regulation of tumor necrosis factor production 12/966 78/17913 9e-04 0.0091 12
GO:0050821 protein stabilization 20/966 171/17913 9e-04 0.0092 20
GO:0000209 protein polyubiquitination 29/966 288/17913 9e-04 0.0092 29
GO:0032648 regulation of interferon-beta production 9/966 48/17913 9e-04 0.0092 9
GO:0043392 negative regulation of DNA binding 9/966 48/17913 9e-04 0.0092 9
GO:0048259 regulation of receptor-mediated endocytosis 14/966 100/17913 9e-04 0.0092 14
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 14/966 100/17913 9e-04 0.0092 14
GO:0042775 mitochondrial ATP synthesis coupled electron transport 13/966 89/17913 9e-04 0.0093 13
GO:0035967 cellular response to topologically incorrect protein 17/966 135/17913 1e-03 0.0095 17
GO:0000187 activation of MAPK activity 18/966 147/17913 1e-03 0.0095 18
GO:0198738 cell-cell signaling by wnt 44/966 500/17913 1e-03 0.0096 44
GO:0070371 ERK1 and ERK2 cascade 29/966 289/17913 1e-03 0.0096 29
GO:0008016 regulation of heart contraction 26/966 249/17913 1e-03 0.0097 26
GO:0007411 axon guidance 23/966 210/17913 1e-03 0.0097 23
GO:2001234 negative regulation of apoptotic signaling pathway 24/966 223/17913 1e-03 0.0098 24
GO:0009167 purine ribonucleoside monophosphate metabolic process 31/966 317/17913 1e-03 0.0100 31

C_{u,3}

ID Description GeneRatio BgRatio pvalue p.adjust Count
GO:0010243 response to organonitrogen compound 57/507 932/17913 0e+00 0.0001 57
GO:0033238 regulation of cellular amine metabolic process 14/507 80/17913 0e+00 0.0001 14
GO:0044106 cellular amine metabolic process 17/507 121/17913 0e+00 0.0001 17
GO:0006521 regulation of cellular amino acid metabolic process 12/507 61/17913 0e+00 0.0001 12
GO:0009308 amine metabolic process 17/507 128/17913 0e+00 0.0001 17
GO:0006457 protein folding 20/507 176/17913 0e+00 0.0001 20
GO:0043620 regulation of DNA-templated transcription in response to stress 16/507 115/17913 0e+00 0.0001 16
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 13/507 77/17913 0e+00 0.0001 13
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 28/507 328/17913 0e+00 0.0001 28
GO:0016071 mRNA metabolic process 50/507 815/17913 0e+00 0.0001 50
GO:0031145 anaphase-promoting complex-dependent catabolic process 13/507 81/17913 0e+00 0.0002 13
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 15/507 109/17913 0e+00 0.0002 15
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 14/507 95/17913 0e+00 0.0002 14
GO:1901699 cellular response to nitrogen compound 41/507 620/17913 0e+00 0.0002 41
GO:0019725 cellular homeostasis 49/507 814/17913 0e+00 0.0002 49
GO:0060218 hematopoietic stem cell differentiation 13/507 83/17913 0e+00 0.0002 13
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 13/507 85/17913 0e+00 0.0002 13
GO:1901532 regulation of hematopoietic progenitor cell differentiation 13/507 85/17913 0e+00 0.0002 13
GO:1902036 regulation of hematopoietic stem cell differentiation 12/507 72/17913 0e+00 0.0002 12
GO:0035567 non-canonical Wnt signaling pathway 17/507 145/17913 0e+00 0.0002 17
GO:0043632 modification-dependent macromolecule catabolic process 36/507 522/17913 0e+00 0.0002 36
GO:0070646 protein modification by small protein removal 24/507 273/17913 0e+00 0.0002 24
GO:1903311 regulation of mRNA metabolic process 24/507 275/17913 0e+00 0.0002 24
GO:0006511 ubiquitin-dependent protein catabolic process 35/507 510/17913 0e+00 0.0003 35
GO:0051050 positive regulation of transport 53/507 942/17913 0e+00 0.0003 53
GO:0016579 protein deubiquitination 23/507 260/17913 0e+00 0.0003 23
GO:0010498 proteasomal protein catabolic process 29/507 382/17913 0e+00 0.0003 29
GO:0071417 cellular response to organonitrogen compound 37/507 559/17913 0e+00 0.0003 37
GO:0019941 modification-dependent protein catabolic process 35/507 515/17913 0e+00 0.0003 35
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 14/507 107/17913 0e+00 0.0003 14
GO:0006520 cellular amino acid metabolic process 27/507 347/17913 0e+00 0.0004 27
GO:0090175 regulation of establishment of planar polarity 14/507 109/17913 0e+00 0.0004 14
GO:0062012 regulation of small molecule metabolic process 31/507 439/17913 0e+00 0.0005 31
GO:1902750 negative regulation of cell cycle G2/M phase transition 13/507 97/17913 0e+00 0.0005 13
GO:0044257 cellular protein catabolic process 40/507 648/17913 0e+00 0.0005 40
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 11/507 69/17913 0e+00 0.0005 11
GO:0009725 response to hormone 51/507 920/17913 0e+00 0.0005 51
GO:0002223 stimulatory C-type lectin receptor signaling pathway 14/507 113/17913 0e+00 0.0005 14
GO:0090276 regulation of peptide hormone secretion 19/507 199/17913 0e+00 0.0005 19
GO:0000086 G2/M transition of mitotic cell cycle 21/507 238/17913 0e+00 0.0005 21
GO:0014070 response to organic cyclic compound 49/507 879/17913 0e+00 0.0006 49
GO:0002220 innate immune response activating cell surface receptor signaling pathway 14/507 116/17913 0e+00 0.0006 14
GO:2000736 regulation of stem cell differentiation 14/507 116/17913 0e+00 0.0006 14
GO:0030072 peptide hormone secretion 21/507 241/17913 0e+00 0.0006 21
GO:0010389 regulation of G2/M transition of mitotic cell cycle 18/507 185/17913 0e+00 0.0006 18
GO:0006397 mRNA processing 33/507 499/17913 0e+00 0.0006 33
GO:0008015 blood circulation 34/507 523/17913 0e+00 0.0006 34
GO:0038095 Fc-epsilon receptor signaling pathway 17/507 169/17913 0e+00 0.0006 17
GO:0023061 signal release 30/507 433/17913 0e+00 0.0006 30
GO:0030104 water homeostasis 11/507 74/17913 0e+00 0.0007 11
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 11/507 75/17913 0e+00 0.0008 11
GO:0003013 circulatory system process 34/507 532/17913 0e+00 0.0008 34
GO:0071347 cellular response to interleukin-1 16/507 156/17913 0e+00 0.0008 16
GO:0001736 establishment of planar polarity 14/507 123/17913 0e+00 0.0009 14
GO:0007164 establishment of tissue polarity 14/507 123/17913 0e+00 0.0009 14
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 11/507 78/17913 0e+00 0.0010 11
GO:0046883 regulation of hormone secretion 21/507 254/17913 0e+00 0.0010 21
GO:0002520 immune system development 50/507 938/17913 0e+00 0.0011 50
GO:0051603 proteolysis involved in cellular protein catabolic process 36/507 590/17913 0e+00 0.0011 36
GO:0048534 hematopoietic or lymphoid organ development 48/507 890/17913 0e+00 0.0011 48
GO:0044839 cell cycle G2/M phase transition 21/507 257/17913 0e+00 0.0011 21
GO:0015844 monoamine transport 10/507 66/17913 0e+00 0.0012 10
GO:0050878 regulation of body fluid levels 32/507 499/17913 0e+00 0.0012 32
GO:1905330 regulation of morphogenesis of an epithelium 17/507 181/17913 0e+00 0.0012 17
GO:0017144 drug metabolic process 44/507 792/17913 0e+00 0.0012 44
GO:0036293 response to decreased oxygen levels 26/507 365/17913 0e+00 0.0012 26
GO:0046879 hormone secretion 23/507 301/17913 0e+00 0.0012 23
GO:0030097 hemopoiesis 46/507 847/17913 0e+00 0.0013 46
GO:0070482 response to oxygen levels 27/507 389/17913 0e+00 0.0013 27
GO:0038093 Fc receptor signaling pathway 20/507 241/17913 0e+00 0.0013 20
GO:1902749 regulation of cell cycle G2/M phase transition 18/507 202/17913 0e+00 0.0013 18
GO:0018279 protein N-linked glycosylation via asparagine 7/507 31/17913 0e+00 0.0014 7
GO:0043270 positive regulation of ion transport 21/507 266/17913 0e+00 0.0016 21
GO:0048511 rhythmic process 22/507 287/17913 0e+00 0.0016 22
GO:0018196 peptidyl-asparagine modification 7/507 32/17913 0e+00 0.0016 7
GO:0048002 antigen processing and presentation of peptide antigen 17/507 188/17913 0e+00 0.0017 17
GO:0042593 glucose homeostasis 19/507 227/17913 0e+00 0.0017 19
GO:0015850 organic hydroxy compound transport 19/507 228/17913 0e+00 0.0017 19
GO:0033500 carbohydrate homeostasis 19/507 228/17913 0e+00 0.0017 19
GO:0001666 response to hypoxia 25/507 354/17913 0e+00 0.0017 25
GO:0070498 interleukin-1-mediated signaling pathway 12/507 101/17913 0e+00 0.0017 12
GO:0009914 hormone transport 23/507 311/17913 0e+00 0.0017 23
GO:1901361 organic cyclic compound catabolic process 39/507 685/17913 0e+00 0.0017 39
GO:0008361 regulation of cell size 15/507 154/17913 0e+00 0.0019 15
GO:0046700 heterocycle catabolic process 37/507 641/17913 0e+00 0.0020 37
GO:0044270 cellular nitrogen compound catabolic process 37/507 642/17913 0e+00 0.0020 37
GO:0002478 antigen processing and presentation of exogenous peptide antigen 16/507 174/17913 0e+00 0.0020 16
GO:0001738 morphogenesis of a polarized epithelium 14/507 139/17913 0e+00 0.0022 14
GO:0019884 antigen processing and presentation of exogenous antigen 16/507 176/17913 0e+00 0.0023 16
GO:0032870 cellular response to hormone stimulus 37/507 647/17913 0e+00 0.0023 37
GO:0030163 protein catabolic process 43/507 799/17913 0e+00 0.0023 43
GO:0034655 nucleobase-containing compound catabolic process 35/507 598/17913 0e+00 0.0023 35
GO:0002244 hematopoietic progenitor cell differentiation 15/507 158/17913 0e+00 0.0023 15
GO:0043488 regulation of mRNA stability 15/507 158/17913 0e+00 0.0023 15
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 16/507 178/17913 0e+00 0.0024 16
GO:0010948 negative regulation of cell cycle process 24/507 344/17913 0e+00 0.0025 24
GO:1903530 regulation of secretion by cell 39/507 703/17913 1e-04 0.0025 39
GO:0006259 DNA metabolic process 49/507 964/17913 1e-04 0.0026 49
GO:0034764 positive regulation of transmembrane transport 17/507 199/17913 1e-04 0.0026 17
GO:0009266 response to temperature stimulus 18/507 219/17913 1e-04 0.0026 18
GO:0019439 aromatic compound catabolic process 37/507 655/17913 1e-04 0.0026 37
GO:0050852 T cell receptor signaling pathway 16/507 180/17913 1e-04 0.0026 16
GO:0051046 regulation of secretion 41/507 757/17913 1e-04 0.0026 41
GO:0061564 axon development 28/507 438/17913 1e-04 0.0026 28
GO:0030073 insulin secretion 17/507 200/17913 1e-04 0.0026 17
GO:0019882 antigen processing and presentation 18/507 220/17913 1e-04 0.0026 18
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 15/507 162/17913 1e-04 0.0026 15
GO:0007409 axonogenesis 26/507 393/17913 1e-04 0.0026 26
GO:0060341 regulation of cellular localization 45/507 863/17913 1e-04 0.0027 45
GO:0008380 RNA splicing 28/507 440/17913 1e-04 0.0027 28
GO:0043487 regulation of RNA stability 15/507 163/17913 1e-04 0.0027 15
GO:0070555 response to interleukin-1 16/507 183/17913 1e-04 0.0029 16
GO:0060322 head development 40/507 738/17913 1e-04 0.0029 40
GO:0009611 response to wounding 37/507 665/17913 1e-04 0.0032 37
GO:0000209 protein polyubiquitination 21/507 288/17913 1e-04 0.0032 21
GO:0055082 cellular chemical homeostasis 37/507 666/17913 1e-04 0.0032 37
GO:0044419 interspecies interaction between organisms 47/507 928/17913 1e-04 0.0034 47
GO:0033209 tumor necrosis factor-mediated signaling pathway 15/507 167/17913 1e-04 0.0034 15
GO:0007420 brain development 38/507 694/17913 1e-04 0.0034 38
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 37/507 669/17913 1e-04 0.0034 37
GO:0050796 regulation of insulin secretion 15/507 169/17913 1e-04 0.0038 15
GO:2000027 regulation of animal organ morphogenesis 19/507 250/17913 1e-04 0.0039 19
GO:0019932 second-messenger-mediated signaling 24/507 360/17913 1e-04 0.0039 24
GO:0006970 response to osmotic stress 10/507 82/17913 1e-04 0.0040 10
GO:0006091 generation of precursor metabolites and energy 30/507 502/17913 1e-04 0.0040 30
GO:0010817 regulation of hormone levels 30/507 503/17913 1e-04 0.0041 30
GO:0043065 positive regulation of apoptotic process 36/507 652/17913 1e-04 0.0042 36
GO:0050778 positive regulation of immune response 42/507 809/17913 1e-04 0.0044 42
GO:1901653 cellular response to peptide 24/507 364/17913 1e-04 0.0044 24
GO:0002218 activation of innate immune response 22/507 319/17913 1e-04 0.0044 22
GO:0071375 cellular response to peptide hormone stimulus 21/507 297/17913 1e-04 0.0044 21
GO:0090087 regulation of peptide transport 38/507 706/17913 1e-04 0.0044 38
GO:0034976 response to endoplasmic reticulum stress 19/507 254/17913 1e-04 0.0044 19
GO:0090263 positive regulation of canonical Wnt signaling pathway 13/507 135/17913 1e-04 0.0044 13
GO:0050891 multicellular organismal water homeostasis 9/507 68/17913 1e-04 0.0044 9
GO:0002758 innate immune response-activating signal transduction 21/507 298/17913 1e-04 0.0044 21
GO:0031329 regulation of cellular catabolic process 42/507 814/17913 1e-04 0.0047 42
GO:1901991 negative regulation of mitotic cell cycle phase transition 18/507 235/17913 1e-04 0.0047 18
GO:0043068 positive regulation of programmed cell death 36/507 660/17913 1e-04 0.0048 36
GO:0051928 positive regulation of calcium ion transport 12/507 119/17913 1e-04 0.0049 12
GO:0019221 cytokine-mediated signaling pathway 40/507 764/17913 1e-04 0.0049 40
GO:0048863 stem cell differentiation 18/507 237/17913 1e-04 0.0050 18
GO:0071453 cellular response to oxygen levels 18/507 237/17913 1e-04 0.0050 18
GO:0009408 response to heat 14/507 158/17913 2e-04 0.0055 14
GO:0016032 viral process 42/507 822/17913 2e-04 0.0055 42
GO:1901652 response to peptide 29/507 491/17913 2e-04 0.0055 29
GO:0061013 regulation of mRNA catabolic process 15/507 178/17913 2e-04 0.0056 15
GO:0033674 positive regulation of kinase activity 31/507 541/17913 2e-04 0.0056 31
GO:0038061 NIK/NF-kappaB signaling 15/507 179/17913 2e-04 0.0058 15
GO:0034612 response to tumor necrosis factor 20/507 284/17913 2e-04 0.0058 20
GO:0006836 neurotransmitter transport 18/507 241/17913 2e-04 0.0058 18
GO:0036294 cellular response to decreased oxygen levels 17/507 220/17913 2e-04 0.0058 17
GO:0001819 positive regulation of cytokine production 27/507 446/17913 2e-04 0.0059 27
GO:0002429 immune response-activating cell surface receptor signaling pathway 25/507 399/17913 2e-04 0.0060 25
GO:0002253 activation of immune response 35/507 647/17913 2e-04 0.0062 35
GO:0044068 modulation by symbiont of host cellular process 6/507 31/17913 2e-04 0.0062 6
GO:0098657 import into cell 39/507 751/17913 2e-04 0.0062 39
GO:0044403 symbiont process 44/507 884/17913 2e-04 0.0062 44
GO:0006354 DNA-templated transcription, elongation 11/507 106/17913 2e-04 0.0062 11
GO:0022904 respiratory electron transport chain 11/507 106/17913 2e-04 0.0062 11
GO:0042775 mitochondrial ATP synthesis coupled electron transport 10/507 89/17913 2e-04 0.0062 10
GO:0071356 cellular response to tumor necrosis factor 19/507 266/17913 2e-04 0.0065 19
GO:0007167 enzyme linked receptor protein signaling pathway 47/507 968/17913 2e-04 0.0065 47
GO:0009743 response to carbohydrate 17/507 224/17913 2e-04 0.0066 17
GO:0050851 antigen receptor-mediated signaling pathway 17/507 224/17913 2e-04 0.0066 17
GO:0042773 ATP synthesis coupled electron transport 10/507 90/17913 2e-04 0.0066 10
GO:1901990 regulation of mitotic cell cycle phase transition 26/507 428/17913 2e-04 0.0067 26
GO:0006887 exocytosis 43/507 862/17913 2e-04 0.0067 43
GO:0009894 regulation of catabolic process 45/507 916/17913 2e-04 0.0067 45
GO:0006937 regulation of muscle contraction 14/507 164/17913 2e-04 0.0069 14
GO:0090277 positive regulation of peptide hormone secretion 10/507 91/17913 2e-04 0.0071 10
GO:0045087 innate immune response 44/507 893/17913 3e-04 0.0072 44
GO:0000904 cell morphogenesis involved in differentiation 34/507 632/17913 3e-04 0.0077 34
GO:0010942 positive regulation of cell death 37/507 710/17913 3e-04 0.0077 37
GO:0002790 peptide secretion 32/507 582/17913 3e-04 0.0078 32
GO:0002768 immune response-regulating cell surface receptor signaling pathway 26/507 434/17913 3e-04 0.0079 26
GO:0002791 regulation of peptide secretion 28/507 483/17913 3e-04 0.0079 28
GO:0071407 cellular response to organic cyclic compound 30/507 533/17913 3e-04 0.0080 30
GO:0098810 neurotransmitter reuptake 5/507 22/17913 3e-04 0.0085 5
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 10/507 94/17913 3e-04 0.0087 10
GO:0071456 cellular response to hypoxia 16/507 210/17913 3e-04 0.0087 16
GO:0008217 regulation of blood pressure 14/507 169/17913 3e-04 0.0087 14
GO:0090090 negative regulation of canonical Wnt signaling pathway 14/507 169/17913 3e-04 0.0087 14
GO:0031349 positive regulation of defense response 29/507 512/17913 3e-04 0.0088 29
GO:0043269 regulation of ion transport 34/507 639/17913 3e-04 0.0088 34
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 22/507 344/17913 3e-04 0.0089 22
GO:0000398 mRNA splicing, via spliceosome 22/507 344/17913 3e-04 0.0089 22
GO:1901988 negative regulation of cell cycle phase transition 18/507 254/17913 3e-04 0.0089 18
GO:0006119 oxidative phosphorylation 12/507 131/17913 3e-04 0.0089 12
GO:0030177 positive regulation of Wnt signaling pathway 14/507 170/17913 3e-04 0.0089 14
GO:0044772 mitotic cell cycle phase transition 31/507 565/17913 4e-04 0.0092 31
GO:0007417 central nervous system development 45/507 935/17913 4e-04 0.0092 45
GO:0002757 immune response-activating signal transduction 31/507 567/17913 4e-04 0.0097 31
GO:0034767 positive regulation of ion transmembrane transport 13/507 152/17913 4e-04 0.0098 13
GO:1903706 regulation of hemopoiesis 27/507 468/17913 4e-04 0.0099 27
GO:0000375 RNA splicing, via transesterification reactions 22/507 348/17913 4e-04 0.0099 22